THE FACT ABOUT POS88 THAT NO ONE IS SUGGESTING

, 2006; Sawaya and Kraut, 1997; Figure 1—figure complement 1), we expected the mutational landscape of DHFR to generally be constrained by the prerequisite to undertake these different conformations. In addition, prior function had prompt DHFR is impacted by cellular constraints which include protein high quality Manage (Bershtein et al., 2013)